Microtubules in Mitosis.
نویسندگان
چکیده
منابع مشابه
Mitosis, microtubules, and the matrix
The mechanical events of mitosis depend on the action of microtubules and mitotic motors, but whether these spindle components act alone or in concert with a spindle matrix is an important question.
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tween a radial array of microtubules during interphase Introduction and a bipolar spindle of microtubules during mitosis. Neurons are the principle signaling cells of the nervous The microtubules are associated with their sites of nusystem. In order to transmit signals, neurons stop dividcleation within the single interphase centrosome or ing early in development and direct their efforts instea...
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The formation of microtubule-derived structures is thought to involve nucleation in all directions and stabilization of microtubules that contact relevant targets. A recent study indicates, during mitosis, there may be a third step, in which microtubule growth is directed over long distances without physical contact between the target and microtubules.
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Concentration gradients of soluble proteins are believed to be responsible for control of morphogenesis of subcellular systems, but the mechanisms that generate the spatial organization of these subcellular gradients remain poorly understood. Here, we use a newly developed multipoint fluorescence fluctuation spectroscopy technique to study the ras-related nuclear protein (Ran) pathway, which fo...
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The Pak kinases are targets of the Rho GTPases Rac and Cdc42, which regulate cell shape and motility. It is increasingly apparent that part of this function is due to the effect Pak kinases have on microtubule organization and dynamics. Recently, overexpression of Xenopus Pak5 was shown to enhance microtubule stabilization, and it was shown that mammalian Pak1 may inhibit a microtubule-destabil...
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ژورنال
عنوان ژورنال: Cell Structure and Function
سال: 1994
ISSN: 0386-7196,1347-3700
DOI: 10.1247/csf.19.57